Clinical geneticists' views of VACTERL/VATER association

L1-associated diseases: clinical geneticists divide, molecular geneticists unite.

The neuronal cell adhesion molecule L1 (L1CAM) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and is essential in the development of the nervous system. It is mainly expressed on neurons and Schwann cells, and plays a key role in axon outgrowth and pathfinding through interactions with various extracellular ligands and intracellular second messenger systems. Mutatio...

Training of medical geneticists.

A role for genetic counsellors and clinical geneticists in pharmacogenetics?

To the Editor : We were interested to read Haga et al.’s report of a survey of genetic counsellors and clinical geneticists’ use and attitudes towards pharmacogenetic testing (1). Recently, we have taken a different approach by conducting in-depth semi-structured interviews with genetic counsellors (2) and clinical geneticists in the UK to explore their attitudes to pharmacogenetics and whether...

Quarreling geneticists and a diplomat.

I N the 1950s the hydrogen bomb was new; it was also fearsome. Some of the test explosions produced debris that was dispersed by high-altitude winds, dropping radioactive fallout over an entire hemisphere. Some geneticists feared that mutations induced by the radiation would constitute a significant genetic hazard to future generations. Other people argued that the tests were a necessary part o...

Clinical Views: Object-Oriented Views for Clinical Databases

We present here a prototype ofa clinical information system for the archiving and the management of multimedia and temporally-oriented clinical data related to PTCA patients. The system is based on an object-oriented DBMS and supports multiple views and view schemas on patients' data. Remote data access is supported too.